![]() Anatomic dead space is age dependent and is > 3 ml/kg in early infancy. The following relationship between total anatomic dead space (DStotal in ml/kg) and age (in yr) is derived: DStotal = 3.28 - 0.56, with r = 0.95 and P = 0.0001. Mean intrathoracic anatomic dead space was 1.03 ml/kg and was not related to age. alveolar dead space the difference between anatomical dead space. ![]() the portions of the respiratory tract that are ventilated but not perfused by pulmonary circulation. ![]() Extrathoracic dead space per kilogram decreased exponentially with increasing age, ranging from 2.3 ml/kg in early infancy to 0.8 ml/kg in children older than 6 yr. a space remaining in the tissues as a result of failure of proper closure of surgical or other wounds, permitting the accumulation of blood or serum. Intrathoracic dead space was measured by continuous analysis of end-tidal and mixed-expired PCO2 and minute ventilation in 10 patients, aged 18 days to 14.7 yr. Extrathoracic dead space was measured by a "water displacement" technique in 40 patients aged 7 days to 14.2 yr who were intubated with cuffed endotracheal tubes. Because of the relatively large head size of infants and children, we hypothesized that extrathoracic and, therefore, total dead space would be relatively larger in pediatric subjects. In adults, anatomic dead space is 2.2 ml/kg.
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